I2c/SPI/USB/UART use for GPIO

Can I repurpose the I2C, SPI, USB, UART headers on the X1 for simple GPIO through python for my project?

No support.
BIOS modification is required.
If you are a commercial user, you can contact: charles@youyeetoo.com to discuss customization service.

If you can expand 48 GPIOs through a USB adapter module, does this fit your needs?